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Chapter 2: Neoplasms

Functional activity
All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code fromChapter 4 may be used, to identify functional activity associated with any neoplasm.
Morphology [Histology]
Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ,benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, suchas for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in thecategory and codes.
Primary malignant neoplasms overlapping site boundaries
A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified tothe subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multipleneoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codesfor each site should be assigned.
Malignant neoplasm of ectopic tissue
Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignantneoplasms are coded to pancreas, unspecified (C25.9).
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C00-C14Malignant neoplasms of lip, oral cavity and pharynx
C15-C26Malignant neoplasms of digestive organs
C30-C39Malignant neoplasms of respiratory and intrathoracic organs
C40-C41Malignant neoplasms of bone and articular cartilage
C43-C44Melanoma and other malignant neoplasms of skin
C45-C49Malignant neoplasms of mesothelial and soft tissue
C50 Malignant neoplasms of breast
C51-C58Malignant neoplasms of female genital organs
C60-C63Malignant neoplasms of male genital organs
C64-C68Malignant neoplasms of urinary tract
C69-C72Malignant neoplasms of eye, brain and other parts of central nervous system
C73-C75Malignant neoplasms of thyroid and other endocrine glands
C7A Malignant neuroendocrine tumors